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Leger i spesialisthelsetjenesten bør ikke rekvirere doser høyere enn three hundred mg OMEQ for each døgn til pasienter i poliklinisk behandling ved langvarige smerter som ikke skyldes kreftsykdom.I LAR inngår legemidler som del av et helhetlig rehabiliteringsforløp. I Norge er to alternativer godkjente for bruk i LAR: Buprenorfin eller metadon